Synthesis and Structure-activity Relationship Studies of O-Biphenyl-3-yl Carbamates as Peripherally Restricted Fatty Acid Amide Hydrolase Inhibitors

The peripherally restricted fatty acid amide hydrolase (FAAH) inhibitor URB937 (3, cyclohexylcarbamic acid 3’-carbamoyl-6-hydroxybiphenyl-3-yl ester) is extruded from the brain and spinal cord by the Abcg2 efflux transporter. Despite its inability to enter the central nervous system (CNS), 3 exerts...

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Main Authors: Moreno-Sanz, Guillermo, Duranti, Andrea, Melzig, Laurin, Fiorelli, Claudio, Ruda, Gian Filippo, Colombano, Giampiero, Mestichelli, Paola, Sanchini, Silvano, Tontini, Andrea, Mor, Marco, Bandiera, Tiziano, Scarpelli, Rita, Tarzia, Giorgio, Piomelli, Daniele
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062305/
https://ncbi.nlm.nih.gov/pubmed/23822179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4007017
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