A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis

Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we employed a genome-wide RNAi screen for Myc-synthetic-lethal genes and uncovered a role for the SUMO-activating-enzyme (SAE1/2). Loss of SAE1/2 enzymatic act...

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Hauptverfasser: Kessler, Jessica D., Kahle, Kristopher T., Sun, Tingting, Meerbrey, Kristen L., Schlabach, Michael R., Schmitt, Earlene M., Skinner, Samuel O., Xu, Qikai, Li, Mamie Z., Hartman, Zachary C., Rao, Mitchell, Yu, Peng, Dominguez-Vidana, Rocio, Liang, Anthony C., Solimini, Nicole L., Bernardi, Ronald J., Yu, Bing, Hsu, Tiffany, Golding, Ido, Luo, Ji, Osborne, C. Kent, Creighton, Chad J., Hilsenbeck, Susan G., Schiff, Rachel, Shaw, Chad A., Elledge, Stephen J., Westbrook, Thomas F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059214/
https://ncbi.nlm.nih.gov/pubmed/22157079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1212728
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