A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis

Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we employed a genome-wide RNAi screen for Myc-synthetic-lethal genes and uncovered a role for the SUMO-activating-enzyme (SAE1/2). Loss of SAE1/2 enzymatic act...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Kessler, Jessica D., Kahle, Kristopher T., Sun, Tingting, Meerbrey, Kristen L., Schlabach, Michael R., Schmitt, Earlene M., Skinner, Samuel O., Xu, Qikai, Li, Mamie Z., Hartman, Zachary C., Rao, Mitchell, Yu, Peng, Dominguez-Vidana, Rocio, Liang, Anthony C., Solimini, Nicole L., Bernardi, Ronald J., Yu, Bing, Hsu, Tiffany, Golding, Ido, Luo, Ji, Osborne, C. Kent, Creighton, Chad J., Hilsenbeck, Susan G., Schiff, Rachel, Shaw, Chad A., Elledge, Stephen J., Westbrook, Thomas F.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059214/
https://ncbi.nlm.nih.gov/pubmed/22157079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1212728
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares