Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase

Among breast cancers, triple-negative breast cancer (TNBC) is the most poorly understood and is refractory to current targeted therapies. Using a genetic screen, we identify the PTPN12 tyrosine phosphatase as a tumor suppressor in TNBC. PTPN12 potently suppresses mammary epithelial cell proliferatio...

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Publicado no:Cell
Main Authors: Sun, Tingting, Aceto, Nicola, Meerbrey, Kristen L., Kessler, Jessica D., Zhou, Chunshui, Migliaccio, Ilenia, Nguyen, Don X., Pavlova, Natalya N., Botero, Maria, Huang, Jian, Bernardi, Ronald J., Schmitt, Earlene, Hu, Guang, Li, Mamie Z., Dephoure, Noah, Gygi, Steven P., Rao, Mitchell, Creighton, Chad J., Hilsenbeck, Susan G., Shaw, Chad A., Muzny, Donna, Gibbs, Richard A., Wheeler, David A., Osborne, C. Kent, Schiff, Rachel, Bentires-Alj, Mohamed, Elledge, Stephen J., Westbrook, Thomas F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014607/
https://ncbi.nlm.nih.gov/pubmed/21376233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.02.003
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