Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase

Among breast cancers, triple-negative breast cancer (TNBC) is the most poorly understood and is refractory to current targeted therapies. Using a genetic screen, we identify the PTPN12 tyrosine phosphatase as a tumor suppressor in TNBC. PTPN12 potently suppresses mammary epithelial cell proliferatio...

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Xehetasun bibliografikoak
Argitaratua izan da:Cell
Egile Nagusiak: Sun, Tingting, Aceto, Nicola, Meerbrey, Kristen L., Kessler, Jessica D., Zhou, Chunshui, Migliaccio, Ilenia, Nguyen, Don X., Pavlova, Natalya N., Botero, Maria, Huang, Jian, Bernardi, Ronald J., Schmitt, Earlene, Hu, Guang, Li, Mamie Z., Dephoure, Noah, Gygi, Steven P., Rao, Mitchell, Creighton, Chad J., Hilsenbeck, Susan G., Shaw, Chad A., Muzny, Donna, Gibbs, Richard A., Wheeler, David A., Osborne, C. Kent, Schiff, Rachel, Bentires-Alj, Mohamed, Elledge, Stephen J., Westbrook, Thomas F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014607/
https://ncbi.nlm.nih.gov/pubmed/21376233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.02.003
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