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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
Oncogenic mutations in the small GTPase Ras are highly prevalent in cancer, but an understanding of the vulnerabilities of these cancers is lacking. We undertook a genome-wide RNAi screen to identify synthetic lethal interactions with the KRAS oncogene. We discovered a diverse set of proteins whose...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768667/ https://ncbi.nlm.nih.gov/pubmed/19490893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.05.006 |
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