A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

Oncogenic mutations in the small GTPase Ras are highly prevalent in cancer, but an understanding of the vulnerabilities of these cancers is lacking. We undertook a genome-wide RNAi screen to identify synthetic lethal interactions with the KRAS oncogene. We discovered a diverse set of proteins whose...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Luo, Ji, Emanuele, Michael J., Li, Danan, Creighton, Chad J., Schlabach, Michael R., Westbrook, Thomas F., Wong, Kwok-kin, Elledge, Stephen J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768667/
https://ncbi.nlm.nih.gov/pubmed/19490893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.05.006
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