Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

The genetic dependencies of human cancers widely vary. Here, we catalog this heterogeneity and use it to identify functional gene interactions and genotype-dependent liabilities in cancer. By using genome-wide CRISPR-based screens, we generate a gene essentiality dataset across 14 human acute myeloi...

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Bibliografiset tiedot
Julkaisussa:Cell
Päätekijät: Wang, Tim, Yu, Haiyan, Hughes, Nicholas W., Liu, Bingxu, Kendirli, Arek, Klein, Klara, Chen, Walter W., Lander, Eric S., Sabatini, David M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445660/
https://ncbi.nlm.nih.gov/pubmed/28162770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.01.013
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