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Chronic CRF(1) Receptor Blockade Reduces Heroin Intake Escalation and Dependence-Induced Hyperalgesia
Opioids represent effective drugs for the relief of pain, yet chronic opioid use often leads to a state of increased sensitivity to pain that is exacerbated during withdrawal. A sensitization of pain-related negative affect has been hypothesized to closely interact with addiction mechanisms. Neuroad...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4057367/ https://ncbi.nlm.nih.gov/pubmed/24330252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/adb.12120 |
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