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Corticotropin-releasing factor (CRF) and α(2) adrenergic receptors mediate heroin withdrawal-potentiated startle in rats

Anxiety is one of the early symptoms of opioid withdrawal and contributes to continued drug use and relapse. The acoustic startle response (ASR) is a component of anxiety that has been shown to increase during opioid withdrawal in both humans and animals. We investigated the role of corticotropin-re...

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Autori principali: Park, Paula E., Vendruscolo, Leandro F., Schlosburg, Joel E., Edwards, Scott, Schulteis, Gery, Koob, George F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880138/
https://ncbi.nlm.nih.gov/pubmed/23590881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1461145713000308
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