The NK1 Receptor Antagonist L822429 Reduces Heroin Reinforcement

Genetic deletion of the neurokinin 1 receptor (NK1R) has been shown to decrease the reinforcing properties of opioids, but it is unknown whether pharmacological NK1R blockade has the same effect. Here, we examined the effect of L822429, a rat-specific NK1R antagonist, on the reinforcing properties o...

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Detalhes bibliográficos
Main Authors: Barbier, Estelle, Vendruscolo, Leandro F, Schlosburg, Joel E, Edwards, Scott, Juergens, Nathan, Park, Paula E, Misra, Kaushik K, Cheng, Kejun, Rice, Kenner C, Schank, Jesse, Schulteis, Gery, Koob, George F, Heilig, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629386/
https://ncbi.nlm.nih.gov/pubmed/23303056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.261
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