Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells

Integrating viruses represent robust tools for cellular reprogramming; however, the presence of viral transgenes in induced pluripotent stem cells (iPSCs) is deleterious because it holds the risk of insertional mutagenesis leading to malignant transformation. Here, we combine the robustness of lenti...

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Hauptverfasser: Kadari, Asifiqbal, Lu, Min, Li, Ming, Sekaran, Thileepan, Thummer, Rajkumar P, Guyette, Naomi, Chu, Vi, Edenhofer, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055111/
https://ncbi.nlm.nih.gov/pubmed/24713299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/scrt435
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