Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells

Safety and reliability of transgene integration in human genome continue to pose challenges for stem cell-based gene therapy. Here, we report a baculovirus-transcription activator-like effector nuclease system for AAVS1 locus-directed homologous recombination in human induced pluripotent stem cells...

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Detalhes bibliográficos
Main Authors: Zhu, Haibao, Lau, Cia-Hin, Goh, Sal-Lee, Liang, Qingle, Chen, Can, Du, Shouhui, Phang, Rui-Zhe, Tay, Felix Chang, Tan, Wee-Kiat, Li, Zhendong, Tay, Johan Chin-Kang, Fan, Weimin, Wang, Shu
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799456/
https://ncbi.nlm.nih.gov/pubmed/23945944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt721
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