Zinc Finger Nuclease-Expressing Baculoviral Vectors Mediate Targeted Genome Integration of Reprogramming Factor Genes to Facilitate the Generation of Human Induced Pluripotent Stem Cells

Integrative gene transfer using retroviruses to express reprogramming factors displays high efficiency in generating induced pluripotent stem cells (iPSCs), but the value of the method is limited because of the concern over mutagenesis associated with random insertion of transgenes. Site-specific in...

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Detalhes bibliográficos
Main Authors: Phang, Rui-Zhe, Tay, Felix Chang, Goh, Sal-Lee, Lau, Cia-Hin, Zhu, Haibao, Tan, Wee-Kiat, Liang, Qingle, Chen, Can, Du, Shouhui, Li, Zhendong, Tay, Johan Chin-Kang, Wu, Chunxiao, Zeng, Jieming, Fan, Weimin, Toh, Han Chong, Wang, Shu
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2013
Assuntos:
Embryonic Stem Cells/Induced Pluripotent Stem (iPS) Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841088/
https://ncbi.nlm.nih.gov/pubmed/24167318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2013-0043
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