Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells

Integrating viruses represent robust tools for cellular reprogramming; however, the presence of viral transgenes in induced pluripotent stem cells (iPSCs) is deleterious because it holds the risk of insertional mutagenesis leading to malignant transformation. Here, we combine the robustness of lenti...

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Dettagli Bibliografici
Autori principali: Kadari, Asifiqbal, Lu, Min, Li, Ming, Sekaran, Thileepan, Thummer, Rajkumar P, Guyette, Naomi, Chu, Vi, Edenhofer, Frank
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055111/
https://ncbi.nlm.nih.gov/pubmed/24713299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/scrt435
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