Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells

Integrating viruses represent robust tools for cellular reprogramming; however, the presence of viral transgenes in induced pluripotent stem cells (iPSCs) is deleterious because it holds the risk of insertional mutagenesis leading to malignant transformation. Here, we combine the robustness of lenti...

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Detalhes bibliográficos
Main Authors: Kadari, Asifiqbal, Lu, Min, Li, Ming, Sekaran, Thileepan, Thummer, Rajkumar P, Guyette, Naomi, Chu, Vi, Edenhofer, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055111/
https://ncbi.nlm.nih.gov/pubmed/24713299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/scrt435
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