Somatic Hypermutation at A/T-Rich Oligonucleotide Substrates Shows Different Strand Polarities in Ung-Deficient or -Proficient Backgrounds

A/T mutations at immunoglobulin loci are introduced by DNA polymerase η (Polη) during an Msh2/6-dependent repair process which results in A's being mutated 2-fold more often than T's. This patch synthesis is initiated by a DNA incision event whose origin is still obscure. We report here th...

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Bibliografiska uppgifter
Huvudupphovsmän: Zivojnovic, Marija, Delbos, Frédéric, Girelli Zubani, Giulia, Julé, Amélie, Alcais, Alexandre, Weill, Jean-Claude, Reynaud, Claude-Agnès, Storck, Sébastien
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2014
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054293/
https://ncbi.nlm.nih.gov/pubmed/24710273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01452-13
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