Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs

During somatic hypermutation (SHM) of immunoglobulin genes, uracils introduced by activation-induced cytidine deaminase are processed by uracil-DNA glycosylase (UNG) and mismatch repair (MMR) pathways to generate mutations at G-C and A-T base pairs, respectively. Paradoxically, the MMR-nicking compl...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Girelli Zubani, Giulia, Zivojnovic, Marija, De Smet, Annie, Albagli-Curiel, Olivier, Huetz, François, Weill, Jean-Claude, Reynaud, Claude-Agnès, Storck, Sébastien
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379981/
https://ncbi.nlm.nih.gov/pubmed/28283534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161576
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