Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes

INTRODUCTION: Signal transducer and activator of transcripton-5a (Stat5a) and its close homologue, Stat5b, mediate key physiological effects of prolactin and growth hormone in mammary glands. In breast cancer, loss of nuclear localized and tyrosine phosphorylated Stat5a/b is associated with poor pro...

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Detalhes bibliográficos
Main Authors: Peck, Amy R, Witkiewicz, Agnieszka K, Liu, Chengbao, Klimowicz, Alexander C, Stringer, Ginger A, Pequignot, Edward, Freydin, Boris, Yang, Ning, Ertel, Adam, Tran, Thai H, Girondo, Melanie A, Rosenberg, Anne L, Hooke, Jeffrey A, Kovatich, Albert J, Shriver, Craig D, Rimm, David L, Magliocco, Anthony M, Hyslop, Terry, Rui, Hallgeir
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053108/
https://ncbi.nlm.nih.gov/pubmed/23036105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3328
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