Loss of Nuclear Localized and Tyrosine Phosphorylated Stat5 in Breast Cancer Predicts Poor Clinical Outcome and Increased Risk of Antiestrogen Therapy Failure

PURPOSE: To investigate nuclear localized and tyrosine phosphorylated Stat5 (Nuc-pYStat5) as a marker of prognosis in node-negative breast cancer and as a predictor of response to antiestrogen therapy. PATIENTS AND METHODS: Levels of Nuc-pYStat5 were analyzed in five archival cohorts of breast cance...

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Detalhes bibliográficos
Main Authors: Peck, Amy R., Witkiewicz, Agnieszka K., Liu, Chengbao, Stringer, Ginger A., Klimowicz, Alexander C., Pequignot, Edward, Freydin, Boris, Tran, Thai H., Yang, Ning, Rosenberg, Anne L., Hooke, Jeffrey A., Kovatich, Albert J., Nevalainen, Marja T., Shriver, Craig D., Hyslop, Terry, Sauter, Guido, Rimm, David L., Magliocco, Anthony M., Rui, Hallgeir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2011
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675698/
https://ncbi.nlm.nih.gov/pubmed/21576635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.30.3552
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