Loss of Nuclear Localized and Tyrosine Phosphorylated Stat5 in Breast Cancer Predicts Poor Clinical Outcome and Increased Risk of Antiestrogen Therapy Failure

PURPOSE: To investigate nuclear localized and tyrosine phosphorylated Stat5 (Nuc-pYStat5) as a marker of prognosis in node-negative breast cancer and as a predictor of response to antiestrogen therapy. PATIENTS AND METHODS: Levels of Nuc-pYStat5 were analyzed in five archival cohorts of breast cance...

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Bibliografski detalji
Glavni autori: Peck, Amy R., Witkiewicz, Agnieszka K., Liu, Chengbao, Stringer, Ginger A., Klimowicz, Alexander C., Pequignot, Edward, Freydin, Boris, Tran, Thai H., Yang, Ning, Rosenberg, Anne L., Hooke, Jeffrey A., Kovatich, Albert J., Nevalainen, Marja T., Shriver, Craig D., Hyslop, Terry, Sauter, Guido, Rimm, David L., Magliocco, Anthony M., Rui, Hallgeir
Format: Artigo
Jezik:Inglês
Izdano: American Society of Clinical Oncology 2011
Teme:
Original Reports
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675698/
https://ncbi.nlm.nih.gov/pubmed/21576635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.30.3552
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