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PTP1B Suppresses Prolactin Activation of Stat5 in Breast Cancer Cells

Basal levels of nuclear localized, tyrosine phosphorylated Stat5 are present in healthy human breast epithelia. In contrast, Stat5 phosphorylation is frequently lost during breast cancer progression, a finding that correlates with loss of histological differentiation and poor patient prognosis. Iden...

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Detalhes bibliográficos
Main Authors: Johnson, Kevin J., Peck, Amy R., Liu, Chengbao, Tran, Thai H., Utama, Fransiscus E., Sjolund, Ashley B., Schaber, John D., Witkiewicz, Agnieszka K., Rui, Hallgeir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993292/
https://ncbi.nlm.nih.gov/pubmed/20952588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090399
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