PTP1B Suppresses Prolactin Activation of Stat5 in Breast Cancer Cells

Basal levels of nuclear localized, tyrosine phosphorylated Stat5 are present in healthy human breast epithelia. In contrast, Stat5 phosphorylation is frequently lost during breast cancer progression, a finding that correlates with loss of histological differentiation and poor patient prognosis. Iden...

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Hlavní autoři: Johnson, Kevin J., Peck, Amy R., Liu, Chengbao, Tran, Thai H., Utama, Fransiscus E., Sjolund, Ashley B., Schaber, John D., Witkiewicz, Agnieszka K., Rui, Hallgeir
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2010
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993292/
https://ncbi.nlm.nih.gov/pubmed/20952588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090399
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