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Impaired turnover of prolactin receptor contributes to transformation of human breast cells
Signaling by polypeptide hormone prolactin (PRL) is mediated by its cognate receptor (PRLr). The PRLr is commonly stabilized in human breast cancer due to decreased phosphorylation of residue Ser 349, which when phosphorylated recruits the βTrcp E3 ubiquitin ligase and facilitates PRLr degradation....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664855/ https://ncbi.nlm.nih.gov/pubmed/19276348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4033 |
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