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Prolactin Inhibits Activity of Pyruvate Kinase M2 to Stimulate Cell Proliferation
Mitogenic and prosurvival effects underlie the tumorigenic roles of prolactin (PRL) in the pathogenesis of breast cancer. PRL signaling is mediated through its receptor (PRLr). A proteomics screen identified the pyruvate kinase M2 (PKM2), a glycolytic enzyme known to play an important role in tumori...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Endocrine Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2999476/ https://ncbi.nlm.nih.gov/pubmed/20962042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0219 |
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