Polyubiquitination of Prolactin Receptor Stimulates Its Internalization, Postinternalization Sorting, and Degradation via the Lysosomal Pathway

The ubiquitination of the receptor that mediates signaling induced by the polypeptide pituitary hormone prolactin (PRL) has been shown to lead to the degradation of this receptor and to the ensuing negative regulation of cellular responses to PRL. However, the mechanisms of PRL receptor (PRLr) prote...

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Main Authors: Varghese, Bentley, Barriere, Herve, Carbone, Christopher J., Banerjee, Anamika, Swaminathan, Gayathri, Plotnikov, Alexander, Xu, Ping, Peng, Junmin, Goffin, Vincent, Lukacs, Gergely L., Fuchs, Serge Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519723/
https://ncbi.nlm.nih.gov/pubmed/18573876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00350-08
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