Polyubiquitination of Prolactin Receptor Stimulates Its Internalization, Postinternalization Sorting, and Degradation via the Lysosomal Pathway

The ubiquitination of the receptor that mediates signaling induced by the polypeptide pituitary hormone prolactin (PRL) has been shown to lead to the degradation of this receptor and to the ensuing negative regulation of cellular responses to PRL. However, the mechanisms of PRL receptor (PRLr) prote...

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Bibliografiske detaljer
Main Authors: Varghese, Bentley, Barriere, Herve, Carbone, Christopher J., Banerjee, Anamika, Swaminathan, Gayathri, Plotnikov, Alexander, Xu, Ping, Peng, Junmin, Goffin, Vincent, Lukacs, Gergely L., Fuchs, Serge Y.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519723/
https://ncbi.nlm.nih.gov/pubmed/18573876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00350-08
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