Pore Dynamics and Conductance of RyR1 Transmembrane Domain

Ryanodine receptors (RyR) are calcium release channels, playing a major role in the regulation of muscular contraction. Mutations in skeletal muscle RyR (RyR1) are associated with congenital diseases such as malignant hyperthermia and central core disease (CCD). The absence of high-resolution struct...

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Hlavní autoři: Shirvanyants, David, Ramachandran, Srinivas, Mei, Yingwu, Xu, Le, Meissner, Gerhard, Dokholyan, Nikolay V.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2014
Témata:
Channels and Transporters
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052289/
https://ncbi.nlm.nih.gov/pubmed/24896116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.04.023
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