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A Structural Model of the Pore-Forming Region of the Skeletal Muscle Ryanodine Receptor (RyR1)

Ryanodine receptors (RyRs) are ion channels that regulate muscle contraction by releasing calcium ions from intracellular stores into the cytoplasm. Mutations in skeletal muscle RyR (RyR1) give rise to congenital diseases such as central core disease. The absence of high-resolution structures of RyR...

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Détails bibliographiques
Auteurs principaux: Ramachandran, Srinivas, Serohijos, Adrian W. R., Xu, Le, Meissner, Gerhard, Dokholyan, Nikolay V.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668181/
https://ncbi.nlm.nih.gov/pubmed/19390614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000367
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