G4941K substitution in the pore-lining S6 helix of the skeletal muscle ryanodine receptor increases RyR1 sensitivity to cytosolic and luminal Ca(2+)

The ryanodine receptor ion channel RyR1 is present in skeletal muscle and has a large cytoplasmic N-terminal domain and smaller C-terminal pore-forming domain comprising six transmembrane helices, a pore helix, and a selectivity filter. The RyR1 S6 pore-lining helix has two conserved glycines, Gly-4...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Xu, Le, Mowrey, David D., Chirasani, Venkat R., Wang, Ying, Pasek, Daniel A., Dokholyan, Nikolay V., Meissner, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808763/
https://ncbi.nlm.nih.gov/pubmed/29255089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.803247
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