Structural Determinants of Skeletal Muscle Ryanodine Receptor Gating

Ryanodine receptor type 1 (RyR1) releases Ca(2+) from intracellular stores upon nerve impulse to trigger skeletal muscle contraction. Effector binding at the cytoplasmic domain tightly controls gating of the pore domain of RyR1 to release Ca(2+). However, the molecular mechanism that links effector...

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Bibliographic Details
Main Authors: Ramachandran, Srinivas, Chakraborty, Asima, Xu, Le, Mei, Yingwu, Samsó, Montserrat, Dokholyan, Nikolay V., Meissner, Gerhard
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585052/
https://ncbi.nlm.nih.gov/pubmed/23319589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.433789
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