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Ion-pulling simulations provide insights into the mechanisms of channel opening of the skeletal muscle ryanodine receptor

The type 1 ryanodine receptor (RyR1) mediates Ca(2+) release from the sarcoplasmic reticulum to initiate skeletal muscle contraction and is associated with muscle diseases, malignant hyperthermia, and central core disease. To better understand RyR1 channel function, we investigated the molecular mec...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Mowrey, David D., Xu, Le, Mei, Yingwu, Pasek, Daniel A., Meissner, Gerhard, Dokholyan, Nikolay V.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546034/
https://ncbi.nlm.nih.gov/pubmed/28584051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.760199
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