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Ion-pulling simulations provide insights into the mechanisms of channel opening of the skeletal muscle ryanodine receptor

The type 1 ryanodine receptor (RyR1) mediates Ca(2+) release from the sarcoplasmic reticulum to initiate skeletal muscle contraction and is associated with muscle diseases, malignant hyperthermia, and central core disease. To better understand RyR1 channel function, we investigated the molecular mec...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Mowrey, David D., Xu, Le, Mei, Yingwu, Pasek, Daniel A., Meissner, Gerhard, Dokholyan, Nikolay V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546034/
https://ncbi.nlm.nih.gov/pubmed/28584051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.760199
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