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Ca(2+)-mediated activation of the skeletal-muscle ryanodine receptor ion channel
Cryo-electron micrograph studies recently have identified a Ca(2+)-binding site in the 2,200-kDa ryanodine receptor ion channel (RyR1) in skeletal muscle. To clarify the role of this site in regulating RyR1 activity, here we applied mutational, electrophysiological, and computational methods. Three...
Gorde:
| Argitaratua izan da: | J Biol Chem |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Biochemistry and Molecular Biology
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6302159/ https://ncbi.nlm.nih.gov/pubmed/30341173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004453 |
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