Ca(2+)-mediated activation of the skeletal-muscle ryanodine receptor ion channel

Cryo-electron micrograph studies recently have identified a Ca(2+)-binding site in the 2,200-kDa ryanodine receptor ion channel (RyR1) in skeletal muscle. To clarify the role of this site in regulating RyR1 activity, here we applied mutational, electrophysiological, and computational methods. Three...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Xu, Le, Chirasani, Venkat R., Carter, Jordan S., Pasek, Daniel A., Dokholyan, Nikolay V., Yamaguchi, Naohiro, Meissner, Gerhard
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302159/
https://ncbi.nlm.nih.gov/pubmed/30341173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004453
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