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Ca(2+)-mediated activation of the skeletal-muscle ryanodine receptor ion channel
Cryo-electron micrograph studies recently have identified a Ca(2+)-binding site in the 2,200-kDa ryanodine receptor ion channel (RyR1) in skeletal muscle. To clarify the role of this site in regulating RyR1 activity, here we applied mutational, electrophysiological, and computational methods. Three...
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| Vydáno v: | J Biol Chem |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6302159/ https://ncbi.nlm.nih.gov/pubmed/30341173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004453 |
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