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Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels
The skeletal muscle (RyR1) and cardiac muscle (RyR2) ryanodine receptor calcium release channels contain a single, conserved calmodulin (CaM) binding domain, yet are differentially regulated by CaM. Here, we report that high-affinity [(35)S]CaM binding to RyR1 is driven by favorable enthalpic and en...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2605178/ https://ncbi.nlm.nih.gov/pubmed/18618700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22148 |
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