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Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels

The skeletal muscle (RyR1) and cardiac muscle (RyR2) ryanodine receptor calcium release channels contain a single, conserved calmodulin (CaM) binding domain, yet are differentially regulated by CaM. Here, we report that high-affinity [(35)S]CaM binding to RyR1 is driven by favorable enthalpic and en...

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Autors principals: Meissner, Gerhard, Pasek, Daniel A., Yamaguchi, Naohiro, Ramachandran, Srinivas, Dokholyan, Nikolay V., Tripathy, Ashutosh
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605178/
https://ncbi.nlm.nih.gov/pubmed/18618700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22148
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