Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1

The cardiac ryanodine receptor (RyR2) is inhibited by calmodulin (CaM) and S100A1. Simultaneous substitution of three amino acid residues (W3587A, L3591D, F3603A; RyR2(ADA)) in the CaM binding domain of RyR2 results in loss of CaM inhibition at submicromolar (diastolic) and micromolar (systolic) Ca(...

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Main Authors: Yamaguchi, Naohiro, Chakraborty, Asima, Huang, Tai-Qin, Xu, Le, Gomez, Angela C., Pasek, Daniel A., Meissner, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2013
Assuntos:
Cardiac Excitation and Contraction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727101/
https://ncbi.nlm.nih.gov/pubmed/23666671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00144.2013
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