Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1

The cardiac ryanodine receptor (RyR2) is inhibited by calmodulin (CaM) and S100A1. Simultaneous substitution of three amino acid residues (W3587A, L3591D, F3603A; RyR2(ADA)) in the CaM binding domain of RyR2 results in loss of CaM inhibition at submicromolar (diastolic) and micromolar (systolic) Ca(...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Yamaguchi, Naohiro, Chakraborty, Asima, Huang, Tai-Qin, Xu, Le, Gomez, Angela C., Pasek, Daniel A., Meissner, Gerhard
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
Témata:
Cardiac Excitation and Contraction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727101/
https://ncbi.nlm.nih.gov/pubmed/23666671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00144.2013
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky