Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1

The cardiac ryanodine receptor (RyR2) is inhibited by calmodulin (CaM) and S100A1. Simultaneous substitution of three amino acid residues (W3587A, L3591D, F3603A; RyR2(ADA)) in the CaM binding domain of RyR2 results in loss of CaM inhibition at submicromolar (diastolic) and micromolar (systolic) Ca(...

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Bibliografiske detaljer
Main Authors: Yamaguchi, Naohiro, Chakraborty, Asima, Huang, Tai-Qin, Xu, Le, Gomez, Angela C., Pasek, Daniel A., Meissner, Gerhard
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2013
Fag:
Cardiac Excitation and Contraction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727101/
https://ncbi.nlm.nih.gov/pubmed/23666671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00144.2013
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