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Two EF-hand motifs in ryanodine receptor calcium release channels contribute to isoform-specific regulation by calmodulin
The mammalian ryanodine receptor Ca(2+) release channel (RyR) has a single conserved high affinity calmodulin (CaM) binding domain. However, the skeletal muscle RyR1 is activated and cardiac muscle RyR2 is inhibited by CaM at submicromolar Ca(2+). This suggests isoform-specific domains are involved...
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| Publicado no: | Cell Calcium |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5657546/ https://ncbi.nlm.nih.gov/pubmed/28807150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2017.05.013 |
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