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Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor
Cardiac ryanodine receptor (RyR2) is a homotetramer of 560 kDa polypeptides regulated by calmodulin (CaM), which decreases its open probability at diastolic and systolic Ca(2+) concentrations. Point mutations in the CaM-binding domain of RyR2 (W3587A/L3591D/F3603A, RyR2(ADA)) in mice result in sever...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3779117/ https://ncbi.nlm.nih.gov/pubmed/23836685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.256123 |
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