Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor

Cardiac ryanodine receptor (RyR2) is a homotetramer of 560 kDa polypeptides regulated by calmodulin (CaM), which decreases its open probability at diastolic and systolic Ca(2+) concentrations. Point mutations in the CaM-binding domain of RyR2 (W3587A/L3591D/F3603A, RyR2(ADA)) in mice result in sever...

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Hlavní autoři: Arnáiz-Cot, Juan José, Damon, Brooke James, Zhang, Xiao-Hua, Cleemann, Lars, Yamaguchi, Naohiro, Meissner, Gerhard, Morad, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2013
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779117/
https://ncbi.nlm.nih.gov/pubmed/23836685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.256123
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