Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1

The cardiac ryanodine receptor (RyR2) is inhibited by calmodulin (CaM) and S100A1. Simultaneous substitution of three amino acid residues (W3587A, L3591D, F3603A; RyR2(ADA)) in the CaM binding domain of RyR2 results in loss of CaM inhibition at submicromolar (diastolic) and micromolar (systolic) Ca(...

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Autori principali: Yamaguchi, Naohiro, Chakraborty, Asima, Huang, Tai-Qin, Xu, Le, Gomez, Angela C., Pasek, Daniel A., Meissner, Gerhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2013
Soggetti:
Cardiac Excitation and Contraction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727101/
https://ncbi.nlm.nih.gov/pubmed/23666671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00144.2013
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