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Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules

Mice with three amino acid mutations in the calmodulin binding domain of type-2 ryanodine receptor ion channel (Ryr2(ADA/ADA) mice) have impaired intracellular Ca(2+) handling and cardiac hypertrophy with death at an early age. In this report, the role of signaling molecules implicated in cardiac hy...

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Bibliografiske detaljer
Main Authors: Yamaguchi, Naohiro, Chakraborty, Asima, Pasek, Daniel A., Molkentin, Jeffery D., Meissner, Gerhard
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119098/
https://ncbi.nlm.nih.gov/pubmed/21421818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00719.2010
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