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Inhibition of CaMKII Does Not Attenuate Cardiac Hypertrophy in Mice with Dysfunctional Ryanodine Receptor

In cardiac muscle, the release of calcium ions from the sarcoplasmic reticulum through ryanodine receptor ion channels (RyR2s) leads to muscle contraction. RyR2 is negatively regulated by calmodulin (CaM) and by phosphorylation of Ca(2+)/CaM-dependent protein kinase II (CaMKII). Substitution of thre...

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Detalhes bibliográficos
Main Authors: Chakraborty, Asima, Pasek, Daniel A., Huang, Tai-Qin, Gomez, Angela C., Yamaguchi, Naohiro, Anderson, Mark E., Meissner, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122402/
https://ncbi.nlm.nih.gov/pubmed/25093823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104338
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