Inhibition of CaMKII Does Not Attenuate Cardiac Hypertrophy in Mice with Dysfunctional Ryanodine Receptor

In cardiac muscle, the release of calcium ions from the sarcoplasmic reticulum through ryanodine receptor ion channels (RyR2s) leads to muscle contraction. RyR2 is negatively regulated by calmodulin (CaM) and by phosphorylation of Ca(2+)/CaM-dependent protein kinase II (CaMKII). Substitution of thre...

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Autores principales: Chakraborty, Asima, Pasek, Daniel A., Huang, Tai-Qin, Gomez, Angela C., Yamaguchi, Naohiro, Anderson, Mark E., Meissner, Gerhard
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122402/
https://ncbi.nlm.nih.gov/pubmed/25093823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104338
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