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Ca(2+)-Calmodulin Increases RyR2 Open Probability yet Reduces Ryanoid Association with RyR2
We have shown that physiological levels of Ca(2+)-calmodulin (Ca(2+)CaM; 50–100 nM) activate cardiac ryanodine receptors (RyR2) incorporated into bilayers and increase the frequency of Ca(2+) sparks and waves in cardiac cells. In contrast, it is well known that Ca(2+)CaM inhibits [(3)H]ryanodine bin...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Biophysical Society
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756350/ https://ncbi.nlm.nih.gov/pubmed/19804721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.07.027 |
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