Ca(2+)-Calmodulin Increases RyR2 Open Probability yet Reduces Ryanoid Association with RyR2

We have shown that physiological levels of Ca(2+)-calmodulin (Ca(2+)CaM; 50–100 nM) activate cardiac ryanodine receptors (RyR2) incorporated into bilayers and increase the frequency of Ca(2+) sparks and waves in cardiac cells. In contrast, it is well known that Ca(2+)CaM inhibits [(3)H]ryanodine bin...

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Bibliografiska uppgifter
Huvudupphovsmän: Sigalas, Charalambos, Mayo-Martin, Maria Belen, Jane, David E., Sitsapesan, Rebecca
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Biophysical Society 2009
Ämnen:
Channels and Transporter
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756350/
https://ncbi.nlm.nih.gov/pubmed/19804721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.07.027
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