Ca(2+)-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains

The Ca(2+) sensor calmodulin (CaM) regulates cardiac ryanodine receptor (RyR2)-mediated Ca(2+) release from the sarcoplasmic reticulum. CaM inhibits RyR2 in a Ca(2+)-dependent manner and aberrant CaM-dependent inhibition results in life-threatening cardiac arrhythmias. However, the molecular details...

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Bibliographic Details
Published in:Biochem J
Main Authors: Brohus, Malene, Søndergaard, Mads T., Wayne Chen, Sui Rong, vanPetegem, Filip, Overgaard, Michael T.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6340113/
https://ncbi.nlm.nih.gov/pubmed/30530841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20180545
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