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A Ca(2+)-Binding Domain in RyR1 that Interacts with the Calmodulin Binding Site and Modulates Channel Activity
A fragment of RyR1 (amino acids 4064–4210) is predicted to fold to at least one lobe of calmodulin and to bind Ca(2+). This fragment of RyR1 (R4064–4210) was subcloned, expressed, refolded, and purified. Consistent with the predicted folding pattern, R4064–4210 was found to bind two molecules of Ca(...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1367016/ https://ncbi.nlm.nih.gov/pubmed/16227507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.066092 |
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