Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

BACKGROUND: Recent genome-wide association studies linked variants in TREM2 to a strong increase in the odds of developing Alzheimer’s disease. The mechanism by which TREM2 influences the susceptibility to Alzheimer’s disease is currently unknown. TREM2 is expressed by microglia and is thought to re...

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Autori principali: Ulrich, Jason D, Finn, Mary Beth, Wang, Yaming, Shen, Alice, Mahan, Thomas E, Jiang, Hong, Stewart, Floy R, Piccio, Laura, Colonna, Marco, Holtzman, David M
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049806/
https://ncbi.nlm.nih.gov/pubmed/24893973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-20
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