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TREM2 function impedes tau seeding in neuritic plaques
Variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been associated with increased risk for sporadic, late-onset Alzheimer’s disease (AD). Here we show that germline knockout of Trem2 or the TREM2(R47H) variant reduce microgliosis around amyloid-β (Aβ) plaques and facilitat...
में बचाया:
| में प्रकाशित: | Nat Neurosci |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2019
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6660358/ https://ncbi.nlm.nih.gov/pubmed/31235932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-019-0433-0 |
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