Amyloid-β plaques enhance Alzheimer’s brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

Alzheimer’s disease (AD) is characterized by extracellular amyloid-β (Aβ) plaques and intracellular tau inclusions. However, the exact mechanistic link between these two AD lesions remains enigmatic. Through injection of human AD-brain-derived pathological tau (AD-tau) into Aβ plaque–bearing mouse m...

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Publicado no:Nat Med
Main Authors: He, Zhuohao, Guo, Jing L, McBride, Jennifer D, Narasimhan, Sneha, Kim, Hyesung, Changolkar, Lakshmi, Zhang, Bin, Gathagan, Ronald J, Yue, Cuiyong, Dengler, Christopher, Stieber, Anna, Nitla, Magdalena, Coulter, Douglas A, Abel, Ted, Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M-Y
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760353/
https://ncbi.nlm.nih.gov/pubmed/29200205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4443
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