Amyloid-β plaques enhance Alzheimer’s brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

Alzheimer’s disease (AD) is characterized by extracellular amyloid-β (Aβ) plaques and intracellular tau inclusions. However, the exact mechanistic link between these two AD lesions remains enigmatic. Through injection of human AD-brain-derived pathological tau (AD-tau) into Aβ plaque–bearing mouse m...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Nat Med
Asıl Yazarlar: He, Zhuohao, Guo, Jing L, McBride, Jennifer D, Narasimhan, Sneha, Kim, Hyesung, Changolkar, Lakshmi, Zhang, Bin, Gathagan, Ronald J, Yue, Cuiyong, Dengler, Christopher, Stieber, Anna, Nitla, Magdalena, Coulter, Douglas A, Abel, Ted, Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M-Y
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760353/
https://ncbi.nlm.nih.gov/pubmed/29200205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4443
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