Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

Filamentous tau aggregates are hallmark lesions in numerous neurodegenerative diseases, including Alzheimer’s disease (AD). Cell culture and animal studies showed that tau fibrils can undergo cell-to-cell transmission and seed aggregation of soluble tau, but this phenomenon was only robustly demonst...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Guo, Jing L., Narasimhan, Sneha, Changolkar, Lakshmi, He, Zhuohao, Stieber, Anna, Zhang, Bin, Gathagan, Ronald J., Iba, Michiyo, McBride, Jennifer D., Trojanowski, John Q., Lee, Virginia M.Y.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110027/
https://ncbi.nlm.nih.gov/pubmed/27810929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160833
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