Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

Filamentous tau aggregates are hallmark lesions in numerous neurodegenerative diseases, including Alzheimer’s disease (AD). Cell culture and animal studies showed that tau fibrils can undergo cell-to-cell transmission and seed aggregation of soluble tau, but this phenomenon was only robustly demonst...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Guo, Jing L., Narasimhan, Sneha, Changolkar, Lakshmi, He, Zhuohao, Stieber, Anna, Zhang, Bin, Gathagan, Ronald J., Iba, Michiyo, McBride, Jennifer D., Trojanowski, John Q., Lee, Virginia M.Y.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2016
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110027/
https://ncbi.nlm.nih.gov/pubmed/27810929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160833
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