Activated microglia mitigate Aβ-associated tau seeding and spreading

In Alzheimer’s disease (AD) models, AD risk variants in the microglial-expressed TREM2 gene decrease Aβ plaque–associated microgliosis and increase neuritic dystrophy as well as plaque-associated seeding and spreading of tau aggregates. Whether this Aβ-enhanced tau seeding/spreading is due to loss o...

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Publicado en:J Exp Med
Autores principales: Gratuze, Maud, Chen, Yun, Parhizkar, Samira, Jain, Nimansha, Strickland, Michael R., Serrano, Javier Remolina, Colonna, Marco, Ulrich, Jason D., Holtzman, David M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Rockefeller University Press 2021
Materias:
Brief Definitive Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8190588/
https://ncbi.nlm.nih.gov/pubmed/34100905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20210542
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