Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

BACKGROUND: Recent genome-wide association studies linked variants in TREM2 to a strong increase in the odds of developing Alzheimer’s disease. The mechanism by which TREM2 influences the susceptibility to Alzheimer’s disease is currently unknown. TREM2 is expressed by microglia and is thought to re...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ulrich, Jason D, Finn, Mary Beth, Wang, Yaming, Shen, Alice, Mahan, Thomas E, Jiang, Hong, Stewart, Floy R, Piccio, Laura, Colonna, Marco, Holtzman, David M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049806/
https://ncbi.nlm.nih.gov/pubmed/24893973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-20
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