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Antisense Oligonucleotide Induction of Progerin in Human Myogenic Cells
We sought to use splice-switching antisense oligonucleotides to produce a model of accelerated ageing by enhancing expression of progerin, translated from a mis-spliced lamin A gene (LMNA) transcript in human myogenic cells. The progerin transcript (LMNA Δ150) lacks the last 150 bases of exon 11, an...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4044034/ https://ncbi.nlm.nih.gov/pubmed/24892300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098306 |
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