Antisense Oligonucleotide Induction of Progerin in Human Myogenic Cells

We sought to use splice-switching antisense oligonucleotides to produce a model of accelerated ageing by enhancing expression of progerin, translated from a mis-spliced lamin A gene (LMNA) transcript in human myogenic cells. The progerin transcript (LMNA Δ150) lacks the last 150 bases of exon 11, an...

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Main Authors: Luo, Yue-Bei, Mitrpant, Chalermchai, Adams, Abbie M., Johnsen, Russell D., Fletcher, Sue, Mastaglia, Frank L., Wilton, Steve D.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044034/
https://ncbi.nlm.nih.gov/pubmed/24892300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098306
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